Allergenicity Evaluation of N-(1-Methylheptyl)-N'-Phenyl-p-Phenylenediamine and 2-(Thiocyanomethylthio) Benzothiazole by the Guinea Pig Maximization Test.
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Bioassay of N-phenyl-p-phenylenediamine for possible carcinogenicity.
A bioassay of N-phenyl-p-phenylenediamine for possible carcinogenicity was conducted by administering the test chemical in the diet to Fischer 344 rats and B6C3F1 mice. Groups of 50 rats of each sex were administered N-phenyl-p-phenylenediamine at one of two doses, either 600 or 1,200 ppm, for 78 weeks and were then observed for 26 additional weeks. Matched controls consisted of groups of 20 un...
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Objective(s):According to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. In the current study, a new series ofphenylthiazole derivatives(compounds 4a-4f) was synthesizedand theiranticancer activity was assessed in vitro. Materials and Methods:All synthesized derivatives were evaluated towards three h...
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متن کاملThe determination of phosphorus and phosphatase with N-phenyl-p-phenylenediamine.
Methods for the determination of phosphorus depend almost entirely upon the reduction of phosphomolybdic acid with the formation of a complex blue pigment which is presumably a mixture of molybdenum oxides. Many variations of methodology revolve about the means by which the colored complex is obtained. The method of Fiske and Subbarow (2), in which aminonaphtholsulfonic acid (ANS) is utilized, ...
متن کاملn-phenyl-2-p-tolylthiazole-4-carboxamide derivatives: syn-thesis and cytotoxicity evaluation as anticancer agents
objective(s):according to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. in the current study, a new series ofphenylthiazole derivatives(compounds 4a-4f) was synthesizedand theiranticancer activity was assessed in vitro. materials and methods:all synthesized derivatives were evaluated towards three hu...
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ژورنال
عنوان ژورنال: Journal of Health Science
سال: 2001
ISSN: 1344-9702,1347-5207
DOI: 10.1248/jhs.47.331